Sphingolipids in HDL – Potential markers for adaptation to pregnancy?

Plasma high density lipoprotein (HDL) exhibits many functions that render it an effective endothelial protective agent and may underlie its potential role in protecting the maternal vascular endothelium during pregnancy. In non-pregnant individuals, HDL lipidome is altered metabolic disease compared to healthy individuals linked reduced cholesterol efflux, effect can be reversed by lifestyle management. Specific sphingolipids such as sphingosine-1-phosphate (S1P) have been shown mediate vaso-dilatory effects of plasma via interaction with nitric oxide synthase pathway. This review describes relationship between function pregnancy details how this lost pre-eclampsia, a disorder associated widespread dysfunction. Evidence for sphingolipids, particular S1P ceramide, cardiovascular pre-eclampsia discussed. Available data suggest HDL-S1P HDL-ceramide protection but not preeclampsia. thus are importance adaptation